Beta-blockers, such as labetalol, may cause decreased placental perfusion, fetal and neonatal bradycardia, and hypoglycemia. Should only be used during pregnancy if the benefits outweigh the risks.
May interfere with some lab tests including amphetamine tests.May interact with some medications including other medications used for the treatment of arrhythmias or angina.May cause an intraoperative floppy iris syndrome during cataract surgery.Can mask symptoms of hypoglycemia (such as a fast heartbeat), so should be used with caution in people with diabetes.Rarely, may cause potentially fatal liver damage.Generally, lower maintenance dosages are needed. Elderly people may be more sensitive to the effects of labetalol.Labetalol can cause a narrowing of the airways (bronchoconstriction) in people with asthma or other respiratory diseases.The dosage needs to be tapered off slowly. Sudden discontinuation of labetalol has been associated with an exacerbation of angina, and occasionally heart attacks and arrhythmias.Labetalol is not suitable for people with certain heart conditions including cardiac failure, slow heartbeat (bradycardia), peripheral circulatory disorders (conditions that cause reduced blood flow to the hands or feet), and extremely low blood pressure.This may cause postural hypotension (a noticeable drop in blood pressure when going from a sitting to a standing position). Labetalol lowers blood pressure more when standing than when sitting or lying down.Dizziness, nausea, fatigue, tingling of the scalp or skin, and fluid retention.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Brand names include Normodyne and Trandate.Available in an injectable form and as a tablet.Labetalol may be used alone or in addition to other antihypertensives (such as diuretics).Use at recommended dosages does not appear to have a detrimental effect on kidney function in people with normal kidney function.Blunts the increase in blood pressure and heart rate that occurs during exercise without affecting how well the lungs are perfused with blood.The injectable form of labetalol is only used to treat severe hypertension.Used to lower high blood pressure (hypertension).It has selective alpha-1 adrenergic receptor-blocking activity and nonselective beta-blocking activity. Labetalol belongs to the class of drugs known as beta-blockers.
Labetalol blocks beta-1 receptors in the heart which slows the heart rate and decreases how hard the heart has to work to pump blood around the body, decreasing blood pressure and its "nonselective" action means it also blocks beta-2 receptors in the bronchioles, which can cause a narrowing of the bronchioles and breathing difficulties in people with pre-existing lung disease. There are two types of beta receptors, beta-1 receptors (located in the heart) and beta-2 receptors (located in the bronchioles of the lungs and the arteries of skeletal muscle). Its alpha blockade action prevents epinephrine and norepinephrine from interacting with alpha receptors which decreases vascular resistance, increases vasodilation, and decreases blood pressure overall. Labetalol works on both alpha and beta receptors in the heart to lower blood pressure and slow heart rate.Labetalol may be used to lower blood pressure.Ĭash Box called it "hard driving rock and roll" and said that it "benefits from thoughtful stylization on the part of each musician, as well as the energetic vocals of sassy Ann Wilson." Record World called it an "out-and-out" and said that "this single performs just as the title promises.Medically reviewed by Carmen Fookes, BPharm. Cash Box Top 100.įellow Seattle band Foo Fighters played a version during a 2014 appearance on Late Show with David Letterman, with Ann and Nancy Wilson performing lead vocals and guitar respectively. Billboard Hot 100 and number sixty-seven on the U.S. When released the song did not perform as well as previous Heart singles, reaching number seventy-nine on the U.S. It was released as the third and final single from the band's second album Little Queen in 1977.
" Kick It Out" is a short, fast-tempo hard rock song recorded by the rock band Heart, written by Ann Wilson.
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